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KMID : 0363320080290020375
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 2 p.375 ~ p.384
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The Histopathology of Hyeungbangjihwang-tang Extracts on the Liver Cirrhosis of Fisher 344 Rats Induced by Long Time Carbon Tetrachloride Injection
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Kim Seung-Mo
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Abstract
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Objective : This study was carried out to investigate the effects of oral administration of Hyeungbangjihwang-tang (HBJHT) on the liver cirrhosis of rats induced by Carbon tetrachloride for 10 weeks.
Method : The histopathological changes were observed. The HBJHT extracts were daily dosed at 50, 100 and 200mg/kg for 12 weeks.
Results : Severe hepatocellular necrosis and ballooning, hyperplasia of connective tissue, subdued reduction of hepatic lobule, and hyperplasia of bile duct in portal triad were dramatically decreased in the HBJHT-treated group compared to that of the Carbon tetrachloride-treated control group in histopathological observation. The diameter of hepatic lobules was significantly enlarged in the HBJHT-treated group compared to that of the Carbon tetrachloride-treated control group, and the amounts of connective tissue, degenerative cells and bile ducts were significantly and dose-dependently decreased.
Conclusion : It is concluded that HBJHT has a significant recovering effect on the liver of rats induced by carbon tetrachloride.
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KEYWORD
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Hyeungbangjihwang-tang(HBJHT), liver cirrhosis, Carbon tetrachloride
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